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US 2009/0156545 A1Published application
Substituted Phosphate Esters of Nucleoside Phosphonates
OwnerKarl Y. Hostetler, James R. Beadle +1inventors
InventorsKarl Y. Hostetler, James R. Beadle, Jacqueline C. Ruiz
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Abstract
Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are obtained by attaching the phosphonate nucleoside of interest to alkyloxyalkyl-phosphate or alkyl-phosphate in a phosphate-phosphono anhydride linkage to provide a modified nucleoside phosphonate drug.
Claims42
A compound of formula I:
- or a pharmaceutically active derivative thereof,
- wherein RL is a lipophilic group, Rq is a pharmacologically active phosphonate,
- and y is 1 or 2.
42-45. (canceled)
Dependencies are inferred from the claim text.