A1 adenosine receptor agonists

A compound having the structure of Formula I:

• wherein:
• R1 is hydroxymethyl, —C(O)OR6, or —C(O)NHR6, in which R6 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl, optionally substituted aryl, or optionally substituted heteroaryl;
• R2 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl;
• R3, R4, and R5 are independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, —CO2H, —SO3H, —C(O)OR6, —CH(OH)R6, or C(O)NR6R7, wherein R7 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl, optionally substituted aryl, or optionally substituted heteroaryl,
• or a salt, hydrate, or pharmaceutically acceptable ester thereof.