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US 2009/0156539 A1Published application
Antisense oligonucleotides (odn) against smad7 and uses thereof in medical field
AssigneeGiuliani International Limited
InventorGiovanni Monteleone
Life of this patent
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Abstract
The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological agents, in particular in the treatment of chronic inflammatory bowel disease, such as Crohn's disease and ulcerative colitis.
Claims11
An antisense oligonucleotide against SMAD7 comprising SEQ ID No:
- 16, wherein X is 5-methyl 2′-deoxycitidine 5′-monophosphate and complements thereof.
A pharmaceutical composition suitable for oral administration, comprising an effective amount of SEQ ID NO:
- 16 and a pharmaceutically acceptable excipient, wherein when said pharmaceutical composition is administered orally to a patient, is more effective in treating colitis as compared to administering to a patient the reverse complement of SEQ ID NO:
- 16.
Dependencies are inferred from the claim text.