SNP BINDING SITE FOR microRNAs IN HLA-G
AssigneeThe University of Chicago
InventorsCarole Ober, Zheng Tan, Jihua Fan
Life of this patent
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Abstract
Analysis of microRNA interference with HLA-G expression identified the HLA-G 3′UTR SNP+3142G/C that disrupts a target for microRNA 148 (miR148) and is associated with asthma. The polymorphism is associated with protection from (or susceptibility to) moderate to severe viral infection in the first 3 years of life and asthma by age 6, with an interaction with mother's affection status (asthma). A SNP in the 3′-Untranslated Region (UTR) of HLA-G influences the targeting of 3 micro(mi)RNAs to the gene. Allele-specific targeting of these miRNAs accounts, at least in part, for the association between HLA-G and the risk of asthma.
Claims6
The use of a nucleotide molecule or a microRNA molecule capable of interacting with HLA-G for the preparation of a medicament for the treatment of asthma or viral infection.
Use of HLA-G 3′UTR polymorphism at position +3142 as a predictor of risk factor for asthma.
A composition used to prevent, control or suppress asthma or viral infection, the composition comprising a nucleotide molecule capable of interacting with HLA-G.
A method of identifying a risk factor for asthma, the method comprising:
- (a) determining whether an HLA-G allele includes a cytosine or a guanine at position +3142 of HLA-G gene;
- and
- (b) if cytosine is at position +3142, identifying a risk factor for asthma and protection against viral illness in children of mothers with asthma, and
- (c) if guanine is at position +3142 identifying a risk factor for asthma and protection against viral illness in children of mothers without asthma.
A method for preventing, controlling or suppressing asthma or viral infection, the method comprising:
- (a) providing a nucleotide molecule or a microRNA molecule capable of regulating HLA-G;
- and
- (b) preventing, controlling or suppressing asthma or viral infection by regulating HLA-G expression.
Dependencies are inferred from the claim text.