Norepinepherine Transporter Mutants and Uses Thereof
OwnerRandy D. Blakely, Uhna Sunginventors
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Abstract
The present invention provides norepinepherine transporter (NET) mutants which display altered phosphorylation at site T30 and altered receptor trafficking. Methods for the use of the NET mutants, e.g., screening of compounds which alter NET trafficking, are also provided. A transgenic animal such as a mouse may comprise a NET mutant of the present invention.
Claims19
An isolated nucleic acid sequence encoding a norepinepherine transporter, wherein the norepinepherine transporter comprises a point mutation at or a deletion of the threonine at position 30 (T30) of the norepinepherine transporter.
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A transgenic non-human animal, wherein the transgenic animal expresses a norepinepherine transporter comprising a point mutation at or a deletion of position T30 of the norepinepherine transporter.
23-31. (canceled)
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Dependencies are inferred from the claim text.