Methods and compositions for modulating foxo1 activity and insulin signaling
AssigneeIrm LLC
InventorsCharles Cho, Sumit Chanda, Peter G. Schultz
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Abstract
The invention provides methods for modulating insulin signaling pathway and methods for treating insulin resistance. The methods employ agents which modulate FOXO1 subcellular localization. The invention also provides methods of screening for compounds that modulate insulin signaling related activities such as gluconeogenesis and cell proliferation.
Claims23
A method of treating or ameliorating insulin resistance in a subject, comprising administering to the subject a pharmaceutical composition comprising an effective amount of a compound which down-regulates cellular level or enzymatic activity of PTP-MEG2, thereby treating insulin resistance in the subject.
A method for identifying an agent that modulates insulin signaling, the method comprising:
- (a) screening test compounds to identify one or more modulating compounds which modulate an FOXO1 localization regulator encoded by a polynucleotide selected from the members listed in Tables 1 and 2;
- and
- (b) testing the modulating compounds for ability to modulate an insulin signaling related activity.
Dependencies are inferred from the claim text.