Cell penetrating peptides for intracellular delivery of molecules
AssigneesCentre National De La Recherche Scient., GenoSpectra, Inc.
InventorsGILLES DIVITA, FREDERIC HEITZ, CATHERINE MAY MORRIS, GUDRUN ALDRIAN-HERRADA
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Abstract
The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8(SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.
Claims20
1-23. (canceled)
A cell-penetrating peptide with amino acid sequence selected from the group consisting of GLWRALWRLLRSLWRLLWKA (SEQ ID No:
- 2);
- GLWRALWRALWRSLWKLKRKV (SEQ ID No:
- 3);
- GLWRALWRALRSLWKLKRKV (SEQ ID No:
- 4);
- GLWRALWRGLRSLWKLKRKV (SEQ ID No:
- 5);
- GLWRALWRGLRSLWKKKRKV (SEQ ID No:
- 6);
- GLWRALWRLLRSLWRLLWKA (SEQ ID No:
- 7);
- GLWRALWRALWRSLWKLKWKV (SEQ ID No:
- 8);
- GLWPALWRALWRSLWKSKRKV (SEQ ID No:
- 9);
- GLWPALWRALWRSLWKKKRKV (SEQ ID No:
- 10);
- and
- GLWRALWRLLRSLWRLLWSQ (SEQ ID No:
- 11).
The complex of claim 31, wherein the amino acid sequence of the cell-penetrating peptide is chosen in the group consisting of
- GLWRALWRALWRSLWKLKWKV;
- (SEQ ID No:
- 8)
- GLWRALWRALWRSLWKSKRKV;
- (SEQ ID No:
- 9)
- GLWRALWRALWRSLWKKKRKV;
- (SEQ ID No:
- 10)
- GLWRALWRALWRSLWKLKRKV;
- (SEQ ID No:
- 3)
- GLWRALWRLLRSLWRLLWSQ
- (SEQ ID No:
- 11)
- and
- GLWRALWRLLRSLWRLLWSQPKKKRKV.
- (SEQ ID No:
- 12)
Dependencies are inferred from the claim text.