Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue and as regulators of neuronal stem cell migration
AssigneeMorehouse School of Medicine
InventorByron D. FORD
Life of this patent
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Abstract
Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can ameliorate damage to neuronal tissue caused by stroke or inflammation. Additionally, neuregulin has been found to be useful for enhancement of stem cell migration from the ventricle to the site of injury to the brain.
Claims20
1-21. (canceled)
A method for ameliorating neuronal damage caused by an occlusive stroke, comprising the step of:
- administering an effective amount of neuregulin, in conjunction with a glutamate receptor inhibitor or a clot disrupting agent to a patient who has suffered an occlusive stroke, wherein said neuregulin is administered within 72 hours of the onset of said occlusive stroke and wherein said Neuregulin inhibits inflammation.
A method for enhancing migration of stem cells from an ventricle into a damaged area of the brain of a subject, comprising:
- administering to said subject an effective amount of neuregulin via intrathecal route,
- wherein said neuregulin enhances stem cell migration.
A method of preventing or ameliorating damage to a blood vessel caused by acute mechanical or chemical assault, comprising:
- administering an effective amount of neuregulin intravenously into a subject in need of such treatment,
- wherein said neuregulin inhibits restenosis.
Dependencies are inferred from the claim text.