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US 2009/0156499 A1Published application
Antimicrobial Peptides and Methods of Identifying the Same
AssigneeBoard of Regents of the University of Nebraska
InventorGuangshun Wang
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Abstract
Antimicrobial peptides and methods of identifying the same are provided.
Claims30
An isolated LL-37 peptide having at least 90% homology with amino acid sequence FKRIVQRIKDFLRX1 (SEQ ID NO:
- 10), wherein X1 is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, and 8 amino acids.
An isolated LL-37 peptide having at least 90% homology with amino acid sequence X1RLFDKIRQVIRKFX2 (SEQ ID NO:
- 18), wherein X1 is 0, 1, 2, 3, 4, 5, 6, 7, or 8 amino acids and X2 is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 amino acids.
A method for identifying a core active peptide region of a peptide of interest comprising:
- a) performing a spectroscopy analysis of the peptide of interest;
- b) identifying disordered residues, if any, from the spectroscopy analysis of step a);
- and
- c) removing the residues identified in step b), if any, from the peptide of interest,
- thereby identifying the core active peptide region.
2 more elements
Dependencies are inferred from the claim text.