Non-cytotoxic PAP mutants
AssigneeRutgers, The State University
InventorsNilgun E. Tumer, Katalin A. Hudak, Bijal Parikh
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Abstract
Disclosed are PAP mutants that are less toxic than wild type PAP and that exhibit depurination activity. Also disclosed are transgenic plants that produce the PAP mutants, and methods for preparing the plants. Further disclosed are bioconjugates containing the PAP mutants, pharmaceutical compositions containing the bioconjugates, and methods of administering the compositions to treat disease.
Claims46
A Pokeweed Antiviral Protein (PAP) mutant that is less toxic than wild-type PAP and which exhibits ribosome depurination activity.
A PAP mutant that is less toxic than wild-type PAP and which exhibits ribosome depurination activity, wherein said mutant is an N-terminal domain mutant.
A PAP mutant that is less toxic than wild-type PAP and which exhibits ribosome depurination activity, wherein said mutant is a central domain mutant.
Dependencies are inferred from the claim text.