Methods and compositions for treating and preventing peripheral nerve damage
AssigneeChildren's Medical Center Corporation
InventorsLarry I. Benowitz, Yuqin Yin
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a method for treating and/or preventing peripheral nerve damage in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
Claims23
A method for treating and/or preventing peripheral nerve damage in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin, to thereby treat and/or prevent peripheral nerve damage in the subject.
A method for treating and/or preventing spinal cord injury in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin to thereby treat and/or prevent spinal cord injury in the subject.
An article of manufacture comprising packaging material and a pharmaceutical agent contained within said packaging material, wherein said packaging material comprises a label which indicates said pharmaceutical may be administered, for a sufficient term at an effective dose, for treating and/or preventing peripheral nerve damage together with a pharmaceutically acceptable carrier, wherein the pharmaceutical agent comprises oncomodulin.
A pharmaceutical kit for the treatment and/or prevention of damage to peripheral nerves comprising the combination of:
- (a) oncomodulin;
- (b) an axogenic factor;
- and
- (c) a cAMP modulator.
(canceled)
A method for inhibiting the axogenic effects of oncomodulin on a neuron comprising contacting an inhibitor of oncomodulin to the neuron.
Dependencies are inferred from the claim text.