Promotion of axonal regeneration
OwnerJohn (Chia-Yang) Lin, Arnon Rosenthalinventors
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Abstract
The present invention concerns a method of promoting axonal regeneration. In particular, the invention concerns a method of promoting the growth or regeneration of neurons, and treating disease or conditions associated with the loss, loss of function or dysfunction of nerve cells, in particular thalamic nerve cells, by administering a polypeptide having a high degree of sequence identity with a native sequence Netrin G1 (NGL-1) or an agonist thereof.
Claims36
A method of promoting axonal growth or regeneration comprising delivering to an injured neuron an effective amount of a polypeptide having at least about 80% sequence identity with amino acid residues 44-352 of SEQ ID NO:
- 1 and comprising a transmembrane region, or an agonist thereof.
A method for treating a disease or condition associated with the loss, loss of function or dysfunction of nerve cells comprising delivering to said nerve cells an effective amount of a polypeptide having at least 80% sequence identity with amino acid residues 44-352 of SEQ ID NO:
- 1 and comprising a transmembrane region, or an agonist thereof.
A method for treating a disease or condition associated with the loss, loss of function or dysfunction of nerve cells comprising delivering to said nerve cells an effective amount of a nucleic acid encoding a polypeptide having at least 80% sequence identity with amino acid residues 44-352 of SEQ ID NO:
- 1 and comprising a transmembrane region, or a peptide or polypeptide agonist thereof.
Dependencies are inferred from the claim text.