Acylated GLP-1 Compounds

A GLP-1 analog which is a compound of formula I (SEQ ID No. 2):

• wherein
• Xaa7 is L-histidine, imidazopropionyl, α-hydroxy-histidine, D-histidine, desamino-histidine, 2-amino-histidine, β-hydroxy-histidine, homohistidine, Nα-acetyl-histidine, Nα-formyl-histidine, α-fluoromethyl-histidine, α-methyl-histidine, 3-pyridylalanine, 2-pyridylalanine or 4-pyridylalanine
• Xaa8 is Ala, Gly, Val, Leu, Ile, Thr, Ser, Lys, Aib, (1-aminocyclopropyl) carboxylic acid, (1-aminocyclobutyl) carboxylic acid, (1-aminocyclopentyl) carboxylic acid, (1-aminocyclohexyl) carboxylic acid, (1-aminocycloheptyl) carboxylic acid, or (1-aminocyclooctyl) carboxylic acid;
• Xaa16 is Val or Leu;
• Xaa18 is Ser, Lys or Arg;
• Xaa19 is Tyr or Gln;
• Xaa20 is Leu or Met;
• Xaa22 is Gly, Glu or Aib;
• Xaa23 is Gln, Glu, Lys or Arg;
• Xaa25 is Ala or Val;
• Xaa27 is Glu or Leu;
• Xaa30 is Ala, Glu or Arg;
• Xaa33 is Val or Lys;
• Xaa34 is Lys, Glu, Asn or Arg;
• Xaa35 is Gly or Aib;
• Xaa36 is Arg, Gly or Lys, or is absent;
• Xaa37 is Gly, Ala, Glu, Pro, Lys, or is absent;
• and B and U′ together is the acylated moiety, where U′ is selected from
• m is 0, 1, 2, 3, 4, 5, or 6,
• n is 1, 2 or 3
• s is 0, 1, 2, or 3,
• t is 0, 1, 2, 3, or 4
• p is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, or 23;
• and where B is an acidic group selected from
• where l is 12, 13, 14, 15, 16, 17, 18, 19 or 20;