US 2009/0156477 A1 · Compositions and Methods for Regulating Inflammatory Responses

Abstract

This invention relates, in part, to compositions and methods for the regulation of inflammatory responses. Specifically, the invention relates, in part, to compositions of and methods for using fibroblast growth factor (FGF) proteins, proteoglycans (e.g., syndecans), agents that modulate proteoglycans and agents that affect Wnt signaling. The invention also provides compositions and methods for treating subjects with undesired inflammatory activity and/or diseases associated therewith. The invention further provides, in part, compositions and methods for disrupting intercellular junctions with FGFs, such as for the enhanced delivery of therapeutic agents.

Claims23

Dependent claims

A method for altering an inflammatory response, comprising:

(a) contacting one or more cells affected by the inflammatory response with a composition comprising fibroblast growth factor-1 (FGF1) and at least one other fibroblast growth factor (FGF), wherein the composition is in an amount effective to alter the inflammatory response;
(b) contacting one or more cells affected by the inflammatory response with a composition comprising a stabilized FGF dimer, wherein the composition is in an amount effective to alter the inflammatory response, and wherein the inflammatory response is not associated with a wound, a scar, an ulcerating disease, inflammatory neuropathy or chronic inflammatory demyelinating polyradiculoneuropathy;
or
(c) contacting one or more cells affected by the inflammatory response with a composition comprising an agent that alters Wnt signaling, wherein the composition is in an amount effective to alter the inflammatory response.

1 more element

Dependencies are inferred from the claim text.

Compositions and Methods for Regulating Inflammatory Responses

Life of this patent

Compositions and Methods for Regulating Inflammatory Responses

Life of this patent

Abstract

Claims23