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US 2009/0156460 A1Published application
Cationic betaine precursors to zwitterionic betaines having controlled biological properties
AssigneeUniversity of Washington
InventorsShaoyi Jiang, Shengfu Chen, Zheng Zhang, Gang Cheng, Hong Xue, Louisa R. Carr
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Abstract
Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, therapeutic agent delivery systems that include the cationic polymers, methods for administering a therapeutic agent using the delivery systems, and methods for making and using the cationic polymers, monomers, surfaces, and therapeutic agent delivery systems.
Claims34
A cationic polymer, comprising:
- (a) polymer backbone;
- (b) a plurality of cationic centers, each cationic center covalently coupled to the polymer backbone by a first linker;
- (c) a counter ion associated with each cationic center;
- and
- (d) a hydrolyzable group covalently coupled to each cationic center through a second linker, wherein the hydrolyzable group is hydrolyzable to an anionic center to provide a zwitterionic polymer having the anionic center covalently coupled to the cationic center through the second linker.
2 more elements
A cationic compound, comprising:
- (a) a polymerizable group;
- (b) a cationic center covalently coupled to the polymerizable group by a first linker;
- (c) a counter ion associated with the cationic center;
- and
- (d) a hydrolyzable group covalently coupled to the cationic center through a second linker, wherein the hydrolyzable group is hydrolyzable to an anionic center to provide a zwitterionic compound having the anionic center covalently coupled to the cationic center through the second linker.
2 more elements
A polymer having a plurality of repeating units, the repeating units having the formula:
- —[CH2—C(Rd)]-L1-N+(Ra)(Rb)-L2-A(═O)—ORcX−
- wherein
- —[CH2—C(Rd)]n— defines a polymer backbone having n repeating units;
- Rd is selected from the group consisting of hydrogen, fluorine, trifluoromethyl, and C1-C6 alkyl;
- n is 10 to 10,000;
- N+ is a cationic center;
- Ra and Rb are independently selected from hydrogen, alkyl, and aryl;
- A(═O)—ORc is a hydrolyzable group, wherein A is selected from the group consisting of C, S, SO, P, or PO, and Rc is an alkyl, aryl, acyl, or silyl group that may be further substituted with one or more substituents;
- L1 is a linker that covalently couples the cationic center to the polymer backbone;
- L2 is a linker that covalently couples the cationic center to the hydrolyzable group;
- and
- X− is the counter ion associated with the cationic center.
9 more elements
Dependencies are inferred from the claim text.