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US 2009/0156459 A1Published application
Cationic-Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
AssigneePharmaIN Corporation
InventorsGerardo M. Castillo, Elijah M. Bolotin
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Abstract
The present invention relates to a biocompatible cationic-core carrier composition that has sustained release capability and includes a polymeric backbone, protective chains, poly-cationic moieties and optionally an anionic load molecule.
Claims32
A cationic-core carrier composition comprising:
- (i) a polymeric backbone;
- (ii) a plurality of polymeric protective chains covalently linked and pendant to the polymeric backbone;
- and (iii) a plurality of poly-cationic moieties covalently linked and pendant to the polymeric backbone, each with molecular weight of no more than 25% of the average molecular weight of the protective chains, wherein each protective side chain has a molecular weight between about 400 and 20,000 Daltons.
A cationic-core carrier composition comprising:
- (i) a polymeric backbone;
- (ii) a plurality of polymeric protective chains covalently linked and pendant to the polymeric backbone;
- (iii) a plurality of poly-cationic moieties covalently linked and pendant to the polymeric backbone;
- and (iv) a load molecule dissociably linked to at least one poly-cationic moiety.
1 more element
Dependencies are inferred from the claim text.