US 2009/0156413 A1Published application

Method, system, apparatus and device for discovering and preparing chemical compounds for medical and other uses

AssigneeReverse Proteomics Research Institute Co., Ltd.

InventorsRenpei Nagashima, Takao Isogai, Noriaki Hirayama

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Abstract

Disclosed in this invention are methods, systems, databases, user-interfaces, software, media, and services useful for evaluating interactions between chemical compounds and proteins and for utilizing the information resulting from such evaluation for the purpose of discovering chemical compounds for medical and other fields. An approach termed “reverse proteomics” is disclosed. This invention generates an enormously large pool of new target proteins for drug discovery, novel methods for designing of new drugs, and a previously unthinkable pool of virtually synthesized small molecules for therapeutic uses. This invention is also applicable, for example, to discovery of substitutes for environmentally hazardous chemicals, more effective agrochemicals, and healthier food additives.

Claims8

Dependent claims

A method of screening for an agent that has a pharmacological effect similar to a target compound (C0) having a desired pharmacological effect, the method comprising:

(1) contacting (i) the target compound (C0) that is selected from a compound library and has the desired pharmacological effect with (ii) a population of proteins in a protein library to select one or more proteins or portions of proteins (Pj) that have affinity and specificity to the target compound (C0);
(2) using one of the proteins or portions of proteins (Pj) selected in step (1) as a target protein to select one or more agents that have affinity and specificity to the target protein from the compound library;
and
(3) obtaining an agent that is not identical to the target compound (C0) used in step (1) from the one or more agents selected in step (2), as a candidate compound (C1) that has the desired pharmacological effect.

1 more element

Dependencies are inferred from the claim text.

Facts

Application: 12/320,961Filed 10 Feb 2009
Priority: 14 Sep 2000
Published: 18 Jun 2009
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C40B 30/04
Methods of screening libraries: by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand…
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
G01N 33/6803
Involving proteins, peptides or amino acids: general methods of protein analysis not limited to specific proteins or families of proteins
G01N 33/6845
General methods of protein analysis not limited to specific proteins or families of proteins: methods of identifying protein-protein interactions…

Family

Application60/232,626Us provisional application · filed 14 Sep 2000
Application60/260,867Us provisional application · filed 12 Jan 2001
Application60/272,774Us provisional application · filed 5 Mar 2001
Application60/294,563Us provisional application · filed 1 Jun 2001
Application60/298,900Us provisional application · filed 19 Jun 2001
Application10/276,471Division · filed 11 Jun 2003
Application12/320,961Division
US 2004/0115726 A1Published application
US 2009/0156413 A1This patent

From the US filing history. Foreign family members aren’t listed.