Biological markers for longevity and diseases and uses thereof
AssigneeAlbert Einstein College of Medicine of Yeshiva University
InventorNir Barzilai
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Abstract
This invention provides methods of using of the sizes and levels of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles, the -641 allele of the promoter of the gene encoding apolipoprotein C-3 (APOC-3), the 405 allele of the gene encoding cholesteryl ester transfer protein (CETP), and plasma levels of insulin-like growth factor-1 (IGF-1), adiponectin, CETP and APOC-3, for determining and increasing an individual's likelihood of longevity and of retaining cognitive function during aging, and for determining and decreasing an individual's likelihood of developing a cardiovascular-, metabolic- or age-related disease.
Claims20
1-127. (canceled)
An assay for identifying a compound that increases a subject's likelihood of longevity, increases a subject's likelihood of retaining cognitive function during aging, decreases a subject's likelihood of developing a cardiovascular-related disease, decreases a subject's likelihood of developing a metabolic syndrome, and/or decreases a subject's likelihood of developing an age-related disease, which comprises identifying a compound which:
- (a) increases HDL particle size in the subject's plasma,
- (b) increases LDL particle size in the subject's plasma,
- (c) increases both HDL and LDL particle size in the subject's plasma,
- (d) increases the percentage of large size HDL particles in the subject's plasma,
- (e) increases the percentage of large size LDL particles in the subject's plasma,
- (f) increases the percentage of both large size HDL particles and large size LDL particles in the subject's plasma,
- (g) increases the subject's plasma level of HDL,
- (h) increases the subject's plasma level of insulin-like growth factor-1 (IGF-1),
- (i) increases the subject's plasma level of adiponectin,
- (j) inhibits the activity of the subject's cholesteryl ester transfer protein (CETP), and/or,
- (k) inhibits the activity of the subject's apolipoprotein C-3 (APOC-3).
(canceled)
Dependencies are inferred from the claim text.