Method for producing dendritic cells
AssigneeIsis Innovation Limited
InventorsHerman Waldmann, Paul J. Fairchild, Richard Gardner, Frances Brook
Life of this patent
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Abstract
Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of providing a population of embryonic stem cells; culturing the embryonic stem cells in the presence of a cytokine or combination of cytokines which brings about differentiation of the embryonic stem cells into dendritic cells; and recovering the dendritic cells from the culture. In a further embodiment, the cells may be genetically modified.
Claims11
1-63. (canceled)
A first in vitro cell population comprising human embryonic stem cells and a second in vitro cell population comprising progeny of a portion of the first in vitro cell population, wherein the progeny are dendritic cells.
The first and second cell populations of claim 1, wherein the dendritic cells are immature dendritic cells.
The first and second cell populations of claim 1, wherein the dendritic cells are mature dendritic cells.
The first and second cell populations of claim 1, wherein the dendritic cells express B7-1.
The first and second cell populations of claim 1, wherein the dendritic cells express B7-2.
The first and second cell populations of claim 1, wherein the dendritic cells express MHC II.
The first and second cell populations of claim 1, wherein the dendritic cells express CD11c.
The first and second cell populations of claim 1, wherein the dendritic cells comprise a plurality of dendrite processes.
The first and second cell populations of claim 1, wherein the human embryonic stem cells are genetically modified.
The first and second cell populations of claim 1, wherein the dendritic cells are genetically modified.
Dependencies are inferred from the claim text.