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AssigneeMayo Foundation for Medical Education and Research, a Minnesota corporation
InventorsMark J. Federspiel, Stephen J. Russell, Pranay D. Khare
Estimating the term…
The invention provides methods and materials involved in displaying polypeptide sequences using viruses such as avian leukosis viruses. Specifically, the invention provides nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses as well as methods for making nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses. The invention also provides methods for obtaining displayed polypeptide sequences that interact with biological molecules and/or cells as well as methods for identifying biological molecules that interact with displayed polypeptides.
A polypeptide comprising the sequence set forth in SEQ ID NO:1 and a first amino acid sequence, wherein said first amino acid sequence is heterologous to naturally occurring avian leukosis virus amino acid sequences, and wherein said first amino acid sequence is attached to the amino-terminal portion of said sequence set forth in SEQ ID NO:1.
A plurality of polypeptides, wherein each polypeptide comprises the sequence set forth in SEQ ID NO:1 and a first amino acid sequence, wherein said first amino acid sequence of each polypeptide is heterologous to naturally occurring avian leukosis virus amino acid sequences, and wherein said first amino acid sequence of each polypeptide is attached to the amino-terminal portion of said sequence set forth in SEQ ID NO:1.
A virus comprising a first polypeptide, wherein said first polypeptide comprises the sequence set forth in SEQ ID NO:1 and a first amino acid sequence, wherein said first amino acid sequence is heterologous to naturally occurring avian leukosis virus amino acid sequences, and wherein said first amino acid sequence is attached to the amino-terminal portion of said sequence set forth in SEQ ID NO:1.
A plurality of viruses, wherein each virus comprises a first polypeptide, wherein each first polypeptide comprises the sequence set forth in SEQ ID NO:1 and a first amino acid sequence, wherein said first amino acid sequence is heterologous to naturally occurring avian leukosis virus amino acid sequences, and wherein said first amino acid sequence is attached to the amino-terminal portion of said sequence set forth in SEQ ID NO:1.
Dependencies are inferred from the claim text.