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AssigneeMassachusetts Institute of Technology
InventorsDavid A. Berry, Robert S. Langer, Richard J. Resnick
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This invention relates, in part, to methods and compositions for modulating the water-gas shift reaction (e.g., promoting the water-gas shift forward reaction) or in which the water-gas shift reaction has been modulated. The methods and compositions, therefore, also relate, in part, to increasing the oxidation rate of carbon monoxide (CO), for increasing the availability of CO (e.g., to the carbon monoxide dehydrogenase (CODH) enzyme complex), for removing and/or promoting the release of hydrogen and/or carbon dioxide (CO2), for regulating the redox potential of cells, for preventing free radical damage and/or promoting cell survivability, etc. The invention also relates, in part, to methods and compositions for modulating CODH activity, such as increasing CODH activity. Methods and compositions are also provided for modulating the PSII reaction (e.g., promoting the PSII forward reaction) or in which the PSII reaction has been modulated. The modulation of the PSII reaction can be in conjunction with the modulation of the water-gas shift reaction. The invention also relates, in part, to methods and compositions for modulating PSII activity, such as increasing PSII activity. The invention further relates to uses of the aforementioned methods and compositions. For example, methods and compositions are provided for the production of hydrogen and/or for the elimination of CO. The methods and compositions provided can be used for a variety of industrial and medical applications, and such applications are also provided as part of the invention.
A method for promoting the water-gas shift forward reaction and enhancing hydrogen production in a sample, comprising:
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A method for promoting the water-gas shift forward reaction and enhancing hydrogen production in a sample of cells, comprising:
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A method for promoting the water-gas shift forward reaction, comprising:
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A method for enhancing hydrogen production, comprising:
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A method of increasing the solubility of carbon monoxide (CO) in a sample containing CO, comprising:
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A method of increasing CODH activity, comprising:
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A method of increasing CODH activity, comprising:
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A method of increasing CODH activity, comprising:
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A method of increasing CODH activity, comprising:
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A method of increasing CODH activity, comprising:
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A method of increasing CODH activity, comprising:
-96. (canceled)
A method of enhanced hydrogen production or CO elimination, comprising:
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A composition, comprising:
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A composition, comprising:
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A composition, comprising:
A CODH-containing cell transfected with a nucleic acid that codes for a CO-binding protein.
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A CODH-containing cell transfected with a nucleic acid that codes for a protein that prevents free radical damage or promotes cell survivability.
(canceled)
A culture of cells containing CODH and an agent that promotes the water-gas shift forward reaction.
(canceled)
Dependencies are inferred from the claim text.