Diagnostic method and prognostic tool for rheumatoid arthritis
OwnerMorris Frank Manolson, Svetlana Komarova +6inventors
InventorsMorris Frank Manolson, Svetlana Komarova, Rene Harrison, Artur De Brum Fernandes, Gilles Boire, Lukasz Kurgan, S. Jeffrey Dixon, Stephen M. Sims
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Abstract
The invention relates to a diagnostic method and prognostic tool for rheumatoid arthritis and uses thereof.
Claims5
A method for diagnosing, predicting severity of, and monitoring rheumatoid arthritis in a subject comprising assaying in a sample from the subject the number of osteoclasts derived from peripheral blood mononuclear cells and/or osteoclast apoptosis and/or osteoclast resorptive activity wherein an increase in number of osteoclasts and/or a decrease in osteoclast apoptosis and/or an increase in osteoclast resorptive activity compared to a control sample is indicative of rheumatoid arthritis.
Dependencies are inferred from the claim text.