Screening method of nesfatin-1-action regulating substance or nesfatin-1-like action substance with the use of receptor protein selected from the group consisting of gpr3, gpr6 and gpr12
AssigneesTeijin Pharma Limited, National University Corporation Gunma University
InventorsMasatomo MORI, Hiroshi Eguchi
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Abstract
An object of the present invention is to identify a Nesfatin-1 receptor, and to provide a method for screening or designing a Nesfatin-1-action regulating substance or a Nesfatin-1-like action substance using the Nesfatin-1 receptor. A method for screening a Nesfatin-1-like action substance comprising steps of making a test substance act on a receptor protein selected from the group consisting of GPR3, GPR6 and GPR12, and of identifying the Nesfatin-1-like action substance based on a change of Nesfatin-1 action.
Claims8
A method for screening a Nesfatin-1-like action substance comprising steps of:
- making a test substance act on a receptor protein selected from the group consisting of GPR3, GPR6 and GPR12;
- and
- identifying the Nesfatin-1-like action substance based on a change of Nesfatin-1 action.
A method for screening a Nesfatin-1-action regulating substance comprising steps of:
- making a test substance act on a coexisting system of Nesfatin-1 and a receptor protein selected from the group consisting of GPR3, GPR6 and GPR12;
- and
- identifying the Nesfatin-1-action regulating substance based on a change of Nesfatin-1 action.
A method for screening in silico or designing a Nesfatin-1-action regulating substance or a Nesfatin-1-like action substance based on a Nesfatin-1 receptor structure or a ligand structure, wherein the Nesfatin-1 receptor structure being obtained by a simulation based on a known structure information of GPR3, GPR6 or GPR12.
Dependencies are inferred from the claim text.