Process for diagnosing rheumatic diseases
AssigneeCypress Bioscience, Inc.
InventorsHolger Bang, Wigbert Berg
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Abstract
The invention relates to polypeptides reacting with rheumatism-associated autoantibodies. The invention moreover relates to a diagnostic agent comprising any of said polypeptides, to a diagnostic kit comprising said diagnostic agent and to a process for in vitro detection of rheumatic diseases. The invention furthermore relates to a medicament comprising any of said polypeptides and to the use of said polypeptides for preparing a medicament for the prophylaxis and/or treatment of rheumatic diseases.
Claims33
A polypeptide derived from native vimentin, having SEQ ID No. 1, characterized in that
- it comprises at least one additional arginine residue compared to the native sequence.
A fragment consisting of at least six amino acids, derived from native vimentin having SEQ ID No. 1,
- characterized in that
- it comprises at least one region with at least one additional arginine residue and it exhibits a reactivity to rheumatism-associated autoantibodies.
The use of BF0786 or/and BF0713 proteins for preparing a medicament for the prophylaxis and/or treatment of rheumatic diseases, in particular rheumatoid arthritis.
The use of BF0786 or/and BF0713 proteins as a diagnostic means for detecting rheumatic diseases, in particular rheumatoid arthritis.
The use of epigallocatechin gallate (EGCG) for the prophylaxis or/and treatment of rheumatic diseases, in particular rheumatoid arthritis.
The use of an extract of green tea for the prophylaxis or/and treatment of rheumatic diseases, in particular rheumatoid arthritis.
Dependencies are inferred from the claim text.