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OwnerBruce L. Grasberger, Cynthia Milligan +5inventors
InventorsBruce L. Grasberger, Cynthia Milligan, John C. Spurlino, Ruth A. Steele, Kenneth R. Singleton, Alan C. Gibbs, Francis A. Lewandowski
Estimating the term…
A crystallized human ACC2 CT protein as well as a description of the X-ray diffraction pattern of the crystal are disclosed. The diffraction pattern allows the three dimensional structure of human ACC2 CT to be determined at atomic resolution so that ligand binding sites on human ACC2 CT can be identified and the interactions of ligands with human ACC2 CT amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of human ACC2 and human ACC1 proteins.
A crystal comprising a dimer of human ACC2 CT, or a fragment, or target structural motif or derivative thereof, and a ligand, wherein said ligand is a small molecule inhibitor.
A computer system comprising:
A method of identifying an agent that binds to human actyl-CoA carboxylase 2 or human actyl-CoA carboxylase 1 comprising a step of employing a three dimensional structure of human ACC2 CT that has been cocrystallized with a small molecule inhibitor.
An isolated protein fragment comprising a binding pocket or active site defined by structure coordinates of human ACC2 CT.
A method for the production of a crystal complex comprising a human ACC2 CT polypeptide-ligand comprising:
Dependencies are inferred from the claim text.