Proteins in type 2 diabetes

A test kit for diagnosing a diabetes-related disease or a predisposition, e.g. genetic, for said disease in a mammal, said test kit comprising:

• (A) at least one binding means which specifically binds to at least one marker protein chosen from the group consisting of:
• (a) ATP synthase beta subunit or phosphorylated ATP synthase beta subunit isoforms;
• (b) phosphoglucomutase 1;
• (c) heat shock protein 90 beta;
• (d) creatine kinase B subunit;
• (e) myosin regulatory light chain 2;
• (f) collagen alpha1 (VI) chain;
• (g) 78 kDa glucose-regulated protein;
• (h) a marker protein defined by the characteristics disclosed in table 3 (match nos:
• 199, 303, 391, or 511);
• (B) at least one means for detecting binding, if any, or the level of binding, of a binding means to at least one of said marker proteins;
• and, if necessary,
• (C) at least one means for correlating whether binding, if any, or the level of binding, to said binding means is indicative of the individual mammal having a significantly higher likelihood of having the disease or a (genetic) predisposition for having the disease.