Genomic Sequence of the 5-Lipoxygenase-Activating Protein (FLAP), Polymorphic Markers Thereof and Methods for Detection of Asthma
AssigneeSerono Genetics Institute S.A.
InventorsMARTA BLUMENFELD, ILYA CHUMAKOV, LYDIE BOUGUELERET
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Abstract
The invention concerns the genomic sequence of the FLAP gene. The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma. The invention provides means to determine the predisposition of individuals to diseases involving the leukotriene pathway as well as means for the diagnosis of such diseases and for the prognosis/detection of an eventual treatment response to agents acting on the leukotriene pathway.
Claims7
A method of determining whether an individual is at risk of developing asthma comprising the steps of:
- (a) obtaining a biological sample comprising a nucleic acid from said individual;
- (b) determining the identity of a biallelic marker within said nucleic acid, said nucleic acid comprising SEQ ID NO:
- 1;
- and
- (c) evaluating whether an individual is at increased risk of asthma;
- wherein said biallelic marker is selected from the group consisting of A1 to A28 and combinations thereof.
Dependencies are inferred from the claim text.