Copy number alterations that predict metastatic capability of human breast cancer
AssigneeVeridex, LLC
InventorsYi Zhang, Jack X. Yu, Yuqui Jiang, Yixin Wang
Life of this patent
Estimating the term…
Abstract
Disclosed in this specification is a method of defining chromosome regions of prognostic value by summarizing the significance of all SNPs (single nucleotide polymorphism) in a predetermined section of a chromosome to define chromosome regions of prognostic value. Based on the SNPs in specified genes, a more accurate prognosis for breast cancer may be provided.
Claims14
A method of defining chromosome regions of prognostic value comprising the step of summarizing the significance of all SNPs in a predetermined section of a chromosome to define chromosome regions of prognostic value.
A method for providing a prognosis for human breast cancer comprising the steps of
- obtaining a DNA sample from a human;
- examining the DNA sample for a single nucleotide polymorphism in at least gene selected from the group consisting of SMC4, PDCD10, PREP, CBX3, NUP205, TCEB1, TERF1, TPD52, GGH, TRAM1, ZBTB10, YTHDF3, EIF3E, POLR2K, RPL30, CCNE2, RAD54B, MTERFD1, ENY2, DPY19L4, ZNF623, SCRIB, SLC39A4, ATP6V1G1, TCTN3, PSMA6, STRN3, CLTC, TRIM37, NME1, NME2, RPS6KB1, PPM1D, MED13, SLC35B1, APPBP2, MKS1, C17orf71, HEATR6, TMEM49, USP32, ANKRD40, NME1-NME2, ZNF264, ZNF304, ATP5E, CSTF1, PPP1R3D, AURKA, RAE1, STX16, C20orf43, RAB22A, HDAC1, BSDC1, C1orf9, COX5B, EIF5B, DDX18, TSN, p20, METTL5, MGAT1, TUBB2A, RWDD1, PGM3, FOXO3, CDC40, REV3L, HDAC2, TSPYL4, C6orf60, ASF1A, MED23, TSPYL1, ACTR10, KIAA0247, RARA, KRT10, RIOK3, IMPACT, and combinations thereof;
- providing a prognosis for human breast cancer based on the results of the step of examining the DNA sample.
A method for providing a prognosis for human breast cancer comprising the steps of
- obtaining a DNA sample from a human;
- examining the DNA sample for a single nucleotide polymorphism on at least one chromosome selected from the group consisting of chromosome numbers 1, 2, 3, 4, 5, 6, 7, 9, 10, 11, 12, 14, 16, 17, 18, 19, 20, 21, 23, and combinations thereof, wherein the single nucleotide polymorphism occurs between the corresponding starting base and ending base recited in Tables 7 and 8;
- providing a prognosis for human breast cancer based on the results of the step of examining the DNA sample.
Dependencies are inferred from the claim text.