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US 2009/0155790 A1Published application
Crab-pii directed diagnostics for neoplastic disease
OwnerElias Georges, Anne-Marie Bonneauinventors
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Abstract
Disclosed are methods for diagnosing cancer in a test cell sample or fluid sample by detecting an increase in the level of expression of CRAB-PII in the test cell sample or fluid sample as compared to the level of expression of CRAB-PII in a control cell sample or fluid sample isolated from a normal subject.
Claims50
A method for detecting a neoplasm comprising
- a) obtaining a potentially neoplastic test cell sample and a non-neoplastic control cell sample;
- b) detecting a level of CRAB-PII expression in the test cell sample;
- c) detecting a level of CRAB-PII expression in the control cell sample;
- d) comparing the level of CRAB-PII expression in the test cell sample to the level of
- CRAB-PII expression in the control cell sample, and
- wherein the test cell sample is neoplastic if the level of CRAB-PII expression in the test cell sample is greater than the level of CRAB-PII expression in the control cell sample.
3 more elements
A method for diagnosing cancer in a subject comprising:
- a) obtaining a potentially neoplastic test fluid sample from a subject and a non-neoplastic control fluid sample;
- b) detecting a level of CRAB-PII expression in the test fluid sample;
- c) detecting a level of CRAB-PII expression in the control fluid sample;
- and
- d) comparing the level of CRAB-PII expression in the test fluid sample to the level of
- CRAB-PII expression in the control fluid sample, and
- wherein cancer is diagnosed if the level of CRAB-PII expression in the test fluid sample is greater than the level of CRAB-PII expression in the control fluid sample.
4 more elements
A kit for diagnosing or detecting neoplasia, comprising a probe for the detection of CRAB-PII.
Dependencies are inferred from the claim text.