Aptamers that bind to prion protein
AssigneeThe Ohio State University Research Foundation
InventorsSrinard Sreevatsan, Kaori Nakamura
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Abstract
Compositions are provided in the form of nucleotide aptamerss that are capapble of binding PrP, and in some embodiments, differentially binding PrP isoforms. Also provided are methods for identifying PrP in a sample, and in some embodiments, either selectively removing PrP or PrP isoforms from a sample, or inactivating them within a sample.
Claims17
An isolated polynucleotide selected from the group consisting of the nucleic acids shown in Tables 1 and 3, and in FIGS. 8 and 9.
A method for detecting a PrP comprising contacting a sample with an isolated polynucleotide selected from the group consisting of the nucleic acids shown in Tables 1 and 3, and in FIGS. 8 and 9 and determining if there is binding of said isolated polynucleotide and PrP.
Dependencies are inferred from the claim text.