Dental Implant Coated with Recombinant Bone Morphogenic Protein and Coating Method Thereof

A method for coating a recombinant bone morphogenic protein on the surface of a dental implant, comprising:

• i) a pretreatment step of processing the surface of the implant (implant surface-processing step);
• ii) a step of preparing a recombinant bone morphogenic protein solution by adding 4 mg of the recombinant bone morphogenic protein to 1 ml of acidic buffer solution (BMP solution preparation step);
• iii) placing 60□ of the BMP solution of said step ii) in a 0.5-ml volume polypropylene tube and immersing in the polypropylene tube the implant having fine pores formed on the surface thereof (implant immersion step);
• iv) placing the polypropylene tube having the implant immersed therein in a 1.5-ml volume polypropylene tube, sealing the 1.5-ml volume tube, and freezing the 1.5-ml volume tube in a freezer at −75±0.5° C. for 3-4 hours (first freezing step);
• v) opening the lid of the 1.5-ml volume polypropylene tube frozen in the freezer, and drying the 1.5-ml volume tube in a freeze dryer pre-cooled to 75±5° C. for 8 hours (second freeze-drying step);
• and
• vi) a step of packaging the freeze-dried polypropylene tube in an aseptic environment and storing the packaged tube at room temperature or in a refrigerator in a dehumidified atmosphere (storage step).