Compositions comprising a lipid and copolymer of styrene and maleic acid
AssigneeMalvren Cosmeceutics Limited
InventorStephen Tonge
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Abstract
A composition comprising a lipid and copolymer of styrene and maleic acid, wherein the copolymer of styrene and maleic acid is non-alternating, and wherein the polymer and lipid are in the form of macromolecular assemblies.
Claims93
A composition comprising a lipid and copolymer of styrene and maleic acid, wherein the copolymer of styrene and maleic acid is non-alternating, and wherein the polymer and lipid are in the form of macromolecular assemblies.
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A method of solubilising a lipid in aqueous solution comprising the formation of macromolecular assemblies of the lipid and a copolymer of styrene and maleic acid, wherein the ratio of styrene to maleic acid monomer units is greater than 1:1.
A method of solubilising an active agent having poor aqueous solubility in aqueous solution comprising the formation of macromolecular assemblies of the lipid, active agent and a copolymer of styrene and maleic acid, wherein the ratio of styrene to maleic acid monomer units is greater than 1:1.
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A method for the screening of candidate agents for interaction with a membrane protein or peptide comprising the steps of:
- (i) solubilising a membrane protein or peptide in a composition a lipid and a copolymer of styrene and maleic acid, wherein the ratio of styrene to maleic acid monomer units is greater than 1:1, wherein the polymer and lipid are in the form of macromolecular assemblies;
- (ii) testing a candidate agent to determine whether it interacts with the solubilised membrane protein or peptide.
Dependencies are inferred from the claim text.