Osteoinductive materials
AssigneeBiopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
InventorsJens POHL, Rolf Bechtold, Michael Kruse
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Abstract
The present invention concerns improved osteoinductive materials comprising matrix materials and morphogenetic roteins, wherein depending on the subject matter the proteins may be dimeric or monomeric proteins. The osteoinductive materials according to the present invention have improved properties. The invention further concerns methods for producing the respective improved osteoinductive materials.
Claims23
A method of treating symptoms or conditions of diseases or abnormal conditions of cartilage, bone, connective tissue including tendon and/or ligament, periodontal or dental tissue, neural tissue, tissue of the sensory system, liver, pancreas, cardiac, blood vessels, renal, uterine and thyroid tissue, skin, mucous membranes, endothelium, or epithelium comprising administering an effective amount of an osteoinductive material comprising a matrix material and, adsorbed on inner and/or outer surfaces of this matrix material, morphogenetic protein(s), wherein said osteoinductive material is obtained by contacting the matrix material and the morphogenetic protein(s) under suitable conditions to keep the protein stable and dissolved in a solution, thereby allowing the matrix material to become evenly coated with the morphogenetic protein(s), wherein said suitable conditions are
- (a) using a buffer or solvent which is capable of maintaining a pH above 10.3 during the coating procedure, or
- (b) using a buffer or solvent which has an ionic concentration of 20 mmol/l or less and is capable of maintaining a pH below 5.2 during the coating procedure, or
- (c) using a buffer or solvent which has an ionic concentration of 100 mmol/l or less and is capable of maintaining a pH above 9.5 during the coating procedure.
Dependencies are inferred from the claim text.