Thixotropic oil based vehicle for pharmaceutical compositions
OwnerMartin Kuentzinventor
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Abstract
The present invention relates to a novel thixotropic oily vehicle comprising between about 0.2% to about 5% (w/w) of a colloidal silica and between about 0.2% to about 5% (w/w) of a hydrophilic polymer in an edible oil. The interaction between the hydrophylic polymer and the colloidal silica in the above concentration ranges confers thixotropy and a low viscosity under shear on the solution. The invention also relates to capsules filled with the above thixotropic solution used as a fill mass.
Claims16
A pharmaceutical composition comprising a therapeutically effective amount of a pharmaceutically active substance and a vehicle wherein the vehicle comprises between about 0.2% to about 5% (w/w) of a colloidal silica and between about 0.2% to about 5% (w/w) of polyethylene glycol in an edible oil;
- wherein the vehicle is thixotropic having a yield point above 4 Pa and a viscosity under shear below 300 mPa·s at a shear rate of 100 s−1 and a temperature of 25° C.
The composition of claim 8, wherein the polyethylene glycol has a molecular weight less than about 400 g/mol.
The composition of claim 9, wherein the polyethylene glycol has a molecular weight of about 300 g/mol.
The vehicle of claim 12, wherein the triglyceride oil is selected from the group consisting of corn oil, peanut oil, olive oil, castor oil, and middle chain triglyceride oil.
Dependencies are inferred from the claim text.