Solid Vaccine Formulation
AssigneeALK-Abello A/S
InventorsCharlotte Hejl, Lise Lund Maerkedahl, Hans-Henrik Ipsen, Susanne Sonderkaer, Annette Rommelmayer Lundegaard, Ulla Seppala
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Abstract
The invention relates to a solid vaccine formulation adapted for mucosal administration comprising at least one antigen as active substance, wherein the formulation comprises a lyophilisate of a suspension comprising an oxygen-containing metal salt, the antigen(s) and one or more excipients selected from (i) saccharides, (ii) sugar alcohols, and (iii) amino acids or pharmaceutically acceptable salts thereof.
Claims46
1-43. (canceled)
A solid vaccine formulation adapted for mucosal administration and comprising at least one antigen as active substance, wherein the formulation comprises a lyophilisate of a suspension comprising an oxygen-containing metal salt, the antigen(s) and at least one excipient selected from (i) saccharides, (ii) sugar alcohols and (iii) amino acids or pharmaceutically acceptable salts thereof.
Use of a lyophilisate of a suspension comprising an oxygen-containing metal salt, at least one antigen and at least one excipient selected from (i) saccharides, (ii) sugar alcohols and (iii) amino acids or pharmaceutically acceptable salts thereof, for the preparation of a solid vaccine formulation for mucosal administration.
The use according to claim 41, wherein the non-compressed tablet is a fast-dissolving tablet.
Dependencies are inferred from the claim text.