Preparation of powders containing colloidal particles
AssigneesGerhard Winter, Michael Wiggenhorn, Feyecon Development & Implementation B.V.
InventorsGerhard Winter, Michael Wiggenhorn, Hubert Clemens Pellikaan
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Abstract
The invention discloses a method for preparing a powder from an aqueous liquid which comprises colloidal particles. The method is based on the use of dense-phase extraction media, i.e. near-critical or supercritical fluids. The powder obtained through the method can be reconstituted with an appropriate aqueous liquid to yield a colloidal dispersion. The method is particularly useful for drying and stabilising aqueous colloidal dispersions comprising an active compound, such as a drug substance.
Claims24
1-19. (canceled)
A method for the preparation of a dry powder from an aqueous liquid which comprises colloidal particles, said method comprising the steps of:
- (a) providing an aqueous liquid comprising said colloidal particles and a hydrophilic excipient;
- (b) providing a first dense-phase extraction medium which is at least partially miscible with water, and which is a poor solvent for said hydrophilic excipient and which is a gas at ambient conditions but is provided in a near-critical or supercritical state;
- and
- (c) atomising the aqueous liquid provided in step (a) and contacting it with the first dense-phase extraction medium provided in step (b) while maintaining near-critical or supercritical conditions to obtain solid particles.
Dependencies are inferred from the claim text.