Method of cell storage in a delivery system
AssigneeResearch Foundaton at State University of New York
InventorsBenjamin Chu, Benjamin S. Hsiao, Michael Hadjiargyrou, Dufei Fang, Xinhua Zong, Kwangsok Kim
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Abstract
Cell storage and delivery systems and methods for storing and delivering viable cells to a mammal are disclosed. The cell storage and delivery systems include a biodegradable and/or bioabsorbable fibrous matrix physically associated with viable cells to contain and release the cells at a controlled rate. The biodegradable and/or bioabsorbable matrix can be formed by electrospinning fibers of biodegradable and/or bioabsorbable fiberizable material. The methods include methods for storing viable cells and for delivering viable cells to a mammal using the cell storage and delivery system.
Claims38
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A method for storage of living cells for delivery into a mammal, said method comprising:
- (a) providing a cell delivery system comprising:
- (i) viable cells;
- and
- (ii) a biodegradable and/or bioabsorbable fibrous matrix physically associated with said cells to contain and release said cells at a controlled rate;
- (b) cooling said cell delivery system down to a preservation temperature under conditions which maintain the integrity of said system;
- and
- (c) maintaining said cell delivery system at or below said preservation temperature until a time when delivery is desired.
Dependencies are inferred from the claim text.