Method for producing hydroxyapatite particles
AssigneeLisopharm AG
InventorsVsevolod Nikolaevich Rudin, Igor Vitallevich Melikhov, Vladimir Vasillevich Minaev, Andrei Yurievich Orlov, Viktor Evgenievich Bozhevolnov
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Abstract
This invention relates generally to a preparation of bone repair compositions, and more special refers to a novel technology in preparing a matrix building polymer i.e. collagen with inclusions of hydroxyapatite particles as biomaterial for medical applications. In this composition that consists of hydroxyapatite particles embedded in a matrix at least 50% nm. Said composition is suitable as bone implant material, dental cement and for applications in wound healing.
Claims46
A method for producing HAP particles, in particular subnanodisperse hydroxyapatite particles in a matrix, the method comprising:
- preparing an aqueous solution containing a matrix-building polymer and phosphoric acid.
- preparing an aqueous solution containing calcium hydroxide,
- feeding the polymer solution into the calcium hydroxide solution while subjecting the latter to mechanical action for synthesizing hydroxyapatite particles embedded in the matrix-building polymer,
- wherein the synthesis of the hydroxyapatite particles is started at a pH value of 8 to 9 and terminated at a pH value of 6 to 8, resulting in a suspension whose HAP particle length comes to mainly between 0.35 and 5 nm, mainly between 0.35 and 2.5 nm and/or mainly between 0.35 and 1.2 nm.
(canceled)
A composition comprising hydroxyapatite particles wherein the length of more than 50% of the hydroxyapatite particles is less than 5 nm.
Dependencies are inferred from the claim text.