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AssigneesETH Zurich, Schweizerisches Tropeninstitut
InventorsDaniel B. Werz, Peter H. Seeberger, Marco Tamborrini, Gerd Pluschke
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The present invention relates to conjugates of oligosaccharides of formula 1, wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides, 5 and which are useful for vaccination, methods of synthesis of such conjugates, antibodies against this antigen, hybridoma producing monoclonal antibodies against this antigen, assays using these antibodies for the detection of B. anthracis spores and kits comprising these antibodies, and a vaccine for the prevention of B. anthracis infection comprising the conjugates of oligosaccharides of formula 1. Monoclonal antibodies 10 according to the invention selectively bind to B. anthracis, but not to related bacteria such as B. subtilis, B. cereus and other bacteria of this group such as B. thuringiensis.
An antibody against a conjugate of an oligosaccharide of formula 1
A conjugate of an oligosaccharide of formula 1
The pentasaccharide of formula 1c wherein R is H or a protecting group, and wherein the stereo center indicated by the asterix may be in the α or β form.
(canceled)
Dependencies are inferred from the claim text.