Vaccine
OwnerHelen Susan Atkins, David Neil Harland +2inventors
InventorsHelen Susan Atkins, David Neil Harland, Stephen John Elvin, Richard William Titball
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Abstract
A polypeptide derived from the periplasmic space of Yersinia pestis or a fragment or a variant of said polypeptide for use as a medicament is described. Pharmaceutical compositions comprising such polypeptides, such as OppA from Yersinia pestis, are also described and claimed. In a preferred embodiments the pharmaceutical composition further comprises existing protective antigens from Y. pestis such as F1 and V antigens. Such compositions are protective in mice and may be used as a vaccine for the prophylactic or therapeutic treatment of plague.
Claims16
A polypeptide derived from the periplasmic space of Yersinia pestis or a variant of said polypeptide or a fragment of any of these wherein the polypeptide, variant or fragment produces a protective immune response against Y. pestis, for use when administered to a human or animal.
A pharmaceutical composition comprising a polypeptide derived from the periplasmic space of Yersinia pestis or a variant of said polypeptide that produces a protective immune response against Y. pestis when administered to a human or animal, or a fragment of any of these that produces a protective immune response against Y. pestis when administered to a human or animal, in combination with a pharmaceutically acceptable carrier or excipient.
13-14. (canceled)
Dependencies are inferred from the claim text.