Hcv vaccines
OwnerMichael Buschle, Jurgen Frisch +4inventors
InventorsMICHAEL BUSCHLE, JURGEN FRISCH, CHRISTOPH KLADE, KAREN LINGNAU, WOLFGANG ZAUNER, GERD ZETTLMEISSL
Life of this patent
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Abstract
Disclosed are methods and compositions for inducing immune responses against Hepatitis C virus (HCV). The compositions comprise one or more epitope from a hotspot epitope. In certain embodiments, an HCV vaccine comprising at least two epitopes, each from a different hotspot epitope, is provided.
Claims27
A hepatitis C virus (HCV) vaccine comprising at least two epitopes, each from a different hotspot epitope, wherein a hotspot epitope is defined as an epitope containing peptides selected from the group consisting of:
- KFPGGGQIVGGVYLLPRRGPRLGVRATRK,
- (SEQ ID NO:73)
- GYKVLVLNPSVAAT,
- (SEQ ID NO:60)
- AYAAQGYKVLVLNPSVAAT,
- (SEQ ID NO:14)
- DLMGYIP(A/L)VGAPL,
- (SEQ ID NO:25;
- SEQ ID NO:26)
- GEVQVVSTATQSFLATCINGVCWTV,
- (SEQ ID NO:49)
- HMWNFISGIQYLAGLSTLPGNPA,
- (SEQ ID NO:63)
- VDYPYRLWHYPCT(V/I)N(F/Y)TIFK(V/I)
- (SEQ ID NO:132;
- RMYVGGVEHRL,,
- SEQ ID NO:133;
- SEQ ID NO:134;
- SEQ ID NO:135;
- SEQ ID NO:136;
- SEQ ID NO:137;
- SEQ ID NO:138;
- SEQ ID NO:139;
- SEQ ID NO:140;
- SEQ ID NO:141)
- AAWYELTPAETTVRLR,
- (SEQ ID NO:4)
- GQGWRLLAPITAYSQQTRGLLGCIV,
- (SEQ ID NO:54)
- IGLGKVLVDILAGYGAGVAGALVAFK,
- (SEQ ID NO:70)
- FTDNSSPPAVPQTFQV,
- (SEQ ID NO:46)
- LEDRDRSELSPLLLSTTEW,
- (SEQ ID NO:80)
- YLVAYQATVCARAQAPPPSWD,
- (SEQ ID NO:149)
- MSTNPKPQRKTKRNTNR,
- (SEQ ID NO:93)
- LINTNGSWHINRTALNCNDSL,
- (SEQ ID NO:84)
- TTILGIGTVLDQAET,
- (SEQ ID NO:125)
- FDS(S/V)VLCECYDAG(A/C)AWYE,
- (SEQ ID NO:40;
- SEQ ID NO:41;
- SEQ ID NO:42;
- SEQ ID NO:43;
- SEQ ID NO:44)
- ARLIVFPDLGVRVCEKMALY,
- (SEQ ID NO:8)
- AFCSAMYVGDLCGSV,
- (SEQ ID NO:5)
- GVLFGLAYFSMVGNW,
- (SEQ ID NO:56)
- VVCCSMSYTWTGALITPC,
- (SEQ ID NO:144)
- TRVPYFVRAQGLIRA
- (SEQ ID NO:123)
- and
- TTLLFNILGGWVAAQ.
- (SEQ ID NO:126)
5-6. (canceled)
9-24. (canceled)
30-35. (canceled)
(canceled)
44-47. (canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.