Compositions and methods for the prevention and treatment of autoimmune conditions
AssigneesUTI Limited Partnership, The General Hospital Corporation
InventorsPedro SANTAMARIA, Anna MOORE
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Abstract
The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases.
Claims46
A method of diagnosing, preventing, or treating an autoimmune disorder comprising administering to a subject an antigen-MHC complex operatively coupled to a microparticle or nanoparticle to a subject in an amount sufficient to expand non-pathogenic autoreactive T cells.
A method of expanding non-pathogenic autoreactive T cells comprising administering to a subject an antigen-MHC class I or MHC class II complex in an amount sufficient to stimulate expansion of an anti-pathogenic autoreactive T cell.
A method for protecting pancreatic islets from an autoimmune response comprising administering to a subject an antigen-MHC class I or antigen-MHC class II complex in an amount sufficient to inhibit the destruction of pancreatic islets, wherein the antigen is derived from an autoantigen associated with pancreatic cells.
The method of 29, wherein the autoantigen is a polypeptide, peptide, carbohydrate, or lipid.
A method for diagnosing autoimmunity comprising assessing treatment-induced expansion of non-pathogenic CD8+ or CD4+ T cell responses as an indication of active autoimmunity.
A method for preventing, ameliorating, or treating rejection of transplanted tissues by allogeneic or autoimmune responses comprising administering to a subject an antigen-MHC complex, operatively coupled to a substrate, an amount sufficient to expand an anti-pathogenic autoreactive T cells recognizing alloantigens or autoantigens expressed by the transplanted tissue or organ.
A tolerogenic particle comprising:
- (a) an Au, Pt, Cu, Ag, Co, Ni, Mn, Sm, Nd, Pr, Gd, Ti, Zr, Si, or In microparticle or nanoparticle;
- and
- (b) an antigen-MHC complex coupled to the particle.
Dependencies are inferred from the claim text.