Furin-cleavable peptide linkers for drug-ligand conjugates
OwnerSteve Roberts, Michael S. Lebowitz +1inventors
InventorsSteve Roberts, Michael S. Lebowitz, Hossein A. Ghanbari
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Abstract
Disclosed are certain peptide linkers for conjugating drugs to ligands, and the resulting drug-linker-ligand molecules and compositions thereof. The conjugated molecules useful for the targeted delivery of drugs to the desired cells, and allow for the intracellular release of the drug in cases where the targeted antigen is internalized via the trans Golgi network and not the lysosomal pathway.
Claims14
A drug-linker-ligand conjugate, wherein the ligand is a molecule that specifically binds to a cell surface antigen of a targeted cell population, and wherein the linker is a furin-sensitive cleavage site peptide.
Dependencies are inferred from the claim text.