Tgf-beta binding antibodies
OwnerBryan Edward Jones, James D. Pancook +1inventors
InventorsBryan Edward Jones, James D. Pancook, Scott William Rowlinson
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Abstract
The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal.
Claims5
1-11. (canceled)
A method of treating a cell proliferative disorder, comprising administering to a subject in need thereof an effective amount of a monoclonal antibody that binds TGF-Beta 1, 2, and 3, wherein each heavy chain variable region comprises the amino acid sequence shown in SEQ ID NO:
- 69, and each light chain variable region comprises the amino acid sequence shown in SEQ ID NO:
- 45.
A method of treating a cell proliferative disorder, comprising administering to a subject in need thereof an effective amount of a monoclonal antibody that binds TGF-Beta 1, 2, and 3, wherein each heavy chain comprises the amino acid sequence shown in SEQ ID NO:
- 81 and each light chain comprises the amino acid sequence shown in SEQ ID NO:
- 80.
Dependencies are inferred from the claim text.