Pseudomonas Aeruginosa Outer Membrane Protein PA5158
OwnerJiro Tanaka, Fukuichi Ohsawa +5inventors
InventorsJiro Tanaka, Fukuichi Ohsawa, Takafumi Okutomi, Hiroshi Nagaso, Masashi Kumagai, Takahisa Suzuki, Keiko Otsuka
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Abstract
An object of the present invention is to provide a protein or peptide antigen and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa. According to the present invention, there is provided a protein or peptide derived from Pseudomonas aeruginosa outer membrane protein PA5158 and an antibody against it, for use in the diagnosis, prevention, or treatment of diseases associated with Pseudomonas aeruginosa.
Claims21
An antigen composition comprising a protein antigen or a peptide antigen which can induce the production of an antibody against a Pseudomonas aeruginosa PA5158 protein.
A protein selected from the group consisting of:
- (i) a protein comprising the amino acid sequence of SEQ ID NO:
- 4;
- (ii) a protein which comprises an amino acid sequence of SEQ ID NO:
- 4 in which one or more amino acids are deleted, substituted, inserted, or added, and which is functionally equivalent to a protein consisting of the amino acid sequence of SEQ ID NO:4;
- (iii) a protein which is encoded by a polynucleotide which hybridizes under stringent conditions to a polynucleotide which encodes the amino acid sequence of SEQ ID NO:
- 4, and which is functionally equivalent to a protein consisting of the amino acid sequence of SEQ ID NO:4;
- and
- (iv) a protein which comprises an amino acid sequence having 70% or more identity with the amino acid sequence of SEQ ID NO:
- 4, and which is functionally equivalent to a protein consisting of the amino acid sequence of SEQ ID NO:4.
A peptide comprising the amino acid sequence of SEQ ID NO:
- 5, or an amino acid sequence of SEQ ID NO:
- 5 which contains one to several conservative substitutions.
A peptide comprising the amino acid sequence of SEQ ID NO:
- 6, or an amino acid sequence of SEQ ID NO:
- 6 which contains one to several conservative substitutions.
An antibody against a Pseudomonas aeruginosa PA5158 protein or a portion thereof, or a functional fragment thereof.
A hybridoma deposited under the accession No. FERM BP-10672.
Dependencies are inferred from the claim text.