Use of immunesuppressant receptor
AssigneeOno Pharmaceutical Co., Ltd.
InventorsTomoyuki Odani, Hideaki Tada, Kimiho Moroe
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Abstract
The present invention relates to use of an antagonist of BIR1 (B cell immunoglobulin receptor 1) related to the present invention, a method for screening the antagonist, in addition to subtype polypeptides of BIR1, the polynucleotide encoding them and antibodies for the polypeptides. BIR1 functions as an immunosuppressive receptor, and the antagonist of BIR1 has immunopotentive activity, which is able to use for preventing and/or treating a cancer, an immunodeficiency disease or an infectious disease.
Claims19
An immunopotentiator which comprises an antagonist of a protein having an amino acid sequence identical to or substantially identical to an amino acid sequence selected from the amino acid sequences represented by SEQ ID NOs:1 to 6.
A method for screening an antagonist of a protein having an amino acid sequence identical to or substantially identical to an amino acid sequence selected from the amino acid sequences represented by SEQ ID NOs:1 to 6, which comprises:
- (i) allowing a protein or polypeptide comprising its extracellular region to contact with a ligand in the presence of a compound to be tested;
- (ii) detecting a signal which is changed by the binding of the protein or polypeptide comprising its extracellular region with the ligand;
- and
- (iii) screening a compound which inhibits the binding, by comparing signal strengths (ii) in the presence and absence of the compound to be tested.
A method for screening an antagonist of a protein having an amino acid sequence identical to or substantially identical to an amino acid sequence selected from the amino acid sequences represented by SEQ ID NOs:1 to 6, which comprises:
- (i) allowing a protein or polypeptide comprising its intracellular region to contact with a phosphatase in the presence of a compound to be tested;
- (ii) detecting a signal which is changed by the binding of the protein or polypeptide comprising its intracellular region with the phosphatase;
- and
- (iii) screening a compound which inhibits the binding, by comparing signal strengths in (ii) in the presence and absence of the compound to be tested.
A method for screening an antagonist of a protein having an amino acid sequence identical to or substantially identical to an amino acid sequence selected from the amino acid sequences represented by SEQ ID NOs:1 to 6, which comprises:
- (i) allowing a cell capable of expressing a protein having an amino acid sequence identical to or substantially identical to an amino acid sequence selected from the amino acid sequences represented by SEQ ID NOs:1 to 6, or a protein or polypeptide comprising its extracellular region, to contact with a cell capable of expressing a ligand, or the ligand, in the presence of a compound to be tested;
- (ii) detecting a signal which is changed by the contact in (ii);
- and
- (iii) screening a compound which inhibits the binding by comparing signal strengths of the step (ii) in the presence and absence of the compound to be tested.
A method for immunopotentiation, which comprises administering to a mammal an effective amount of an antagonist of a protein having an amino acid sequence identical to or substantially identical to an amino acid sequence selected from the amino acid sequences represented by SEQ ID NOs:1 to 6.
(canceled)
A method for preventing and/or treating a disease selected from a cancer, an immunodeficiency disease and an infectious disease, which comprises administering to a mammal an effective amount of an antagonist of a protein having an amino acid sequence identical to or substantially identical to an amino acid sequence selected from the amino acid sequences represented by SEQ ID NOs:1 to 6.
(canceled)
A protein having an amino acid sequence identical to or substantially identical to one amino acid sequence selected from the amino acid sequences represented by SEQ ID NOs:3 to 6, or a partial peptide thereof.
A polynucleotide which encodes a protein having an amino acid sequence identical to or substantially identical to one amino acid sequence selected from the amino acid sequences represented by SEQ ID NOs:3 to 6, or a partial peptide thereof.
An antibody for a protein having an amino acid sequence identical to or substantially identical to one amino acid sequence selected from the amino acid sequences represented by SEQ ID NOs:3 to 6, or a partial peptide thereof.
Dependencies are inferred from the claim text.