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US 2009/0155275 A1Published application
Multispecific epitope binding proteins and uses thereof
AssigneeMedImmune, LLC
InventorsHerren WU, Changshou GAO, Carl HAY, Nazzareno DIMASI
Life of this patent
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Abstract
The present invention relates to multispecific epitope binding proteins, methods of making, and uses thereof in the prevention, management, treatment or diagnosis of acute or chronic diseases.
Claims12
1-139. (canceled)
An isolated multispecific epitope binding protein comprising a first and a second polypeptide chain, wherein the first chain comprises a member selected from the group consisting of:
- a. one or more Fc regions linked N-terminal to at least one epitope binding domain (EBD);
- b. one or more Fc regions linked C-terminal to at least one EBD;
- c. at least three or more EBDs;
- d. at least one or more Fc regions;
- e. at least one or more CH1 domains;
- and
- f. at least one or more Cκ or Cλ domains.
4 more elements
An isolated multispecific epitope binding protein comprising a first and a second polypeptide chain, wherein the second chain comprises a member selected from the group consisting of:
- a. one or more Cκ or Cλ regions linked N-terminal to at least one EBD;
- b. one or more Cκ or Cλ regions linked C-terminal to at least one EBD;
- c. at least three or more EBDs;
- d. at least three or more EBDs and at least one or more Cκ or Cλ regions;
- e. at least two or more EBDs, at least one antibody variable region, and a Cκ or Cλ region;
- f. at least one or more CH1 domains;
- and
- g. at least one or more Cκ or Cλ domains.
5 more elements
Dependencies are inferred from the claim text.