Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors
AssigneesAmgen Inc., Medarex, Inc.
InventorsKenneth D. Wild, JR., James J.S. Treanor, Haichun Huang, Heather Inoue, Tie J. Zhang, Frank Martin
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Abstract
This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
Claims16
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an isolated antibody, wherein the antibody comprises a light chain comprising SEQ ID NO:
- 44 and a heavy chain comprising SEQ ID NO:
- 40.
An isolated antibody, wherein the antibody comprises a light chain comprising SEQ ID NO:
- 44 and a heavy chain comprising SEQ ID NO:
- 40 and the heavy chain and light chain of the antibody are connected by a flexible linker to form a single chain antibody.
Dependencies are inferred from the claim text.