Il-17a and il-17f antagonists and methods of using the same
AssigneeZymoGenetics, Inc.
InventorsSTEVEN D. LEVIN, MARK W. RIXON, ZEREN GAO
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Abstract
The present invention relates antagonists of IL-17A and IL-17F. The antagonists of the invention are based on IL-17RC alone or on both IL-17RC and IL-17RA (“IL-17RC/IL-17RA”). Such antagonists serve to block, inhibit, reduce, antagonize or neutralize the activity of IL-17F, IL-17A, or both IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. IL-17RA is a receptor for IL-17A and IL-17RC is a common receptor for both IL-17A and IL-17F. The present invention includes soluble IL-17A and IL-17F anatagonists, as well as methods for using the same.
Claims75
An isolated polypeptide comprising amino acid residues 32-458 of SEQ ID NO:158.
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of amino acid residues 36-718 of SEQ ID NO:68, amino acid residues 21-683 of SEQ ID NO:70, amino acid residues 32-710 of SEQ ID NO:72, amino acid residues 21-526 of SEQ ID NO:106, amino acid residues 32-811 of SEQ ID NO:140, and amino acid residues 36-698 of SEQ ID NO:152.
An isolated nucleic acid molecule encoding a polypeptide, wherein the encoded polypeptide comprises amino acid residues 32-458 of SEQ ID NO:158.
An isolated nucleic acid molecule encoding a polypeptide, wherein the encoded polypeptide comprises an amino acid sequence selected from the group consisting of amino acid residues 36-718 of SEQ ID NO:68, amino acid residues 21-683 of SEQ ID NO:70, amino acid residues 32-710 of SEQ ID NO:72, amino acid residues 21-526 of SEQ ID NO:106, amino acid residues 32-811 of SEQ ID NO:140, and amino acid residues 36-698 SEQ ID NO:152.
An expression vector comprising the following operably linked elements:
- a) a transcription promoter;
- b) a DNA segment encoding a polypeptide wherein the encoded polypeptide comprises amino acid residues 32-458 of SEQ ID NO:158;
- and
- c) a transcription terminator.
An expression vector comprising the following operably linked elements:
- a) a transcription promoter;
- b) a DNA segment encoding a polypeptide wherein the encoded polypeptide comprises an amino acid sequence selected from the group consisting of amino acid residues 36-718 of SEQ ID NO:68, amino acid residues 21-683 of SEQ ID NO:70, amino acid residues 32-710 of SEQ ID NO:72, amino acid residues 21-526 of SEQ ID NO:106, amino acid residues 32-811 of SEQ ID NO:140, and amino acid residues 36-698 SEQ ID NO:152;
- and
- c) a transcription terminator.
A composition comprising:
- an isolated polypeptide comprising amino acid residues 32-458 of SEQ ID NO:158;
- and
- a pharmaceutically acceptable vehicle.
A composition comprising:
- an isolated polypeptide comprising an amino acid sequence selected from the group consisting of amino acid residues 36-718 of SEQ ID NO:68, amino acid residues 21-683 of SEQ ID NO:70, amino acid residues 32-710 of SEQ ID NO:72, amino acid residues 21-526 of SEQ ID NO:106, amino acid residues 32-811 of SEQ ID NO:140, and amino acid residues 36-698 SEQ ID NO:152;
- and
- a pharmaceutically acceptable vehicle.
Dependencies are inferred from the claim text.