Mesothelin antibody protein fusions and methods of use

A fusion protein comprising a stress protein fused in frame with a biotin-binding protein in combination with a biotinylated engineered antibody or fragment thereof, that binds specifically to mesothelin.

A fusion protein comprising a stress protein fused in frame with an antibody binding protein in combination with an engineered antibody or fragment thereof, that binds specifically to mesothelin.

A fusion protein comprising an engineered antibody or fragment thereof, that binds specifically to mesothelin fused in frame with a biotin binding protein.

A fusion protein comprising an engineered antibody or fragment thereof, that binds specifically to mesothelin fused in frame with an antibody binding protein.

The kit of claim 18, further comprising instructions for performing any of the methods of claims 20-23 and 32-33.

A method for inducing an immune response to mesothelin in a subject comprising administering to the subject a fusion protein comprising a stress protein fused in frame with an engineered antibody or fragment thereof, that binds specifically to mesothelin to induce an immune response.

A method of treating a disease in a subject, comprising administering to the subject a fusion protein comprising a stress protein fused in frame with an engineered antibody or fragment thereof, that binds specifically to mesothelin to treat a disease.

A method for inducing an immune response to mesothelin in a subject, comprising administering to said subject a fusion protein comprising a stress protein fused in frame with a biotin-binding protein in combination with a biotinylated engineered antibody or fragment thereof, that binds specifically to mesothelin, to induce an immune response.

A method of treating a disease in a subject, comprising administering to said subject a fusion protein comprising a stress protein fused in frame with a biotin-binding protein in combination with a biotinylated engineered antibody or fragment thereof, that binds specifically to mesothelin, to treat a disease.

A method for inducing an immune response to mesothelin in a subject, comprising administering to said subject a fusion protein comprising an engineered antibody or fragment thereof, that binds specifically to mesothelin, fused in frame with a biotin binding protein to induce an immune response.

A method of treating a disease in a subject, comprising administering to said subject a fusion protein comprising an engineered antibody or fragment thereof, that binds specifically to mesothelin fused in frame with a biotin binding protein to treat a disease.

A method for inducing an immune response to mesothelin in a subject, comprising administering to said subject a fusion protein comprising a stress protein fused in frame with an antibody binding protein in combination with an engineered antibody or fragment thereof, that binds specifically to mesothelin, to induce an immune response.

A method of treating a disease in a subject, comprising administering to said subject a fusion protein comprising a stress protein fused in frame with an antibody binding protein in combination with an engineered antibody or fragment thereof, that binds specifically to mesothelin, to treat a disease.

A method for inducing an immune response to mesothelin in a subject, comprising administering to said subject a fusion protein comprising an engineered antibody or fragment thereof, that binds specifically to mesothelin fused in frame with an antibody binding protein to induce an immune response.

A method of treating a disease in a subject, comprising administering to said subject a fusion protein comprising an engineered antibody or fragment thereof, that binds specifically to mesothelin fused in frame with an antibody binding protein to treat a disease.